PhenoAge Calculator

Scientifically-Validated Biological Age Assessment

Transform your health applications with Lincoln Cannon LLC’s PhenoAge Calculator API. Our implementation of the peer-reviewed PhenoAge algorithm provides accurate biological age assessments using comprehensive biometric markers, offering insights into health status and aging patterns that go far beyond chronological age.

For API documentation and technical details, refer to the PhenoAge Calculator API. For clinical studies and scientific details, see the PhenoAge scientific foundation. Or read about our entire Biometric Calculator suite.

Why Choose PhenoAge?

🔬 Scientifically Validated: Based on peer-reviewed research by Dr. Morgan Levine and validated across diverse populations
📊 Comprehensive Biomarkers: Uses 9 clinical biomarkers for accurate biological age assessment
🎯 Mortality Risk Prediction: Proven to predict all-cause and cause-specific mortality risk
⚡ Enterprise Ready: AWS-powered infrastructure with 99.9% uptime and enterprise-grade security

Part of the Biometric Calculator Suite - Advanced age assessment for health and wellness applications.

What Makes PhenoAge Special?

🔬 Peer-Reviewed Scientific Foundation

PhenoAge is based on groundbreaking research published in PLOS Medicine:

Validated Algorithm: Tested on 11,000+ adults in the NHANES IV cohort
Mortality Prediction: Proven to predict all-cause and cause-specific mortality
Population Diversity: Validated across different ethnicities and age groups
Clinical Relevance: Used in clinical research and preventive medicine worldwide

📊 Comprehensive Biomarker Analysis

PhenoAge uses 9 essential clinical biomarkers for accurate assessment:

Age: Chronological age as baseline reference
Albumin: Protein levels indicating nutritional and liver function
Alkaline Phosphatase (ALP): Liver and bone health marker
Creatinine: Kidney function indicator
C-Reactive Protein (CRP): Inflammation marker (log-transformed)
Glucose: Blood sugar levels and metabolic health
Lymphocyte Percentage: Immune system function
Mean Corpuscular Volume (MCV): Red blood cell health
Red Blood Cell Distribution Width (RDW): Blood cell uniformity
White Blood Cell Count (WBC): Immune system activity

🎯 Advanced Algorithm Features

Our PhenoAge implementation includes sophisticated mathematical processing:

Two-Step Calculation: Raw PhenoAge and age-adjusted PhenoAge
Log Transformation: CRP values are log-transformed for optimal weighting
Age Correction: Statistical adjustment reduces age-related bias
Validation Checks: Ensures biologically plausible results
Legacy Support: Maintains compatibility with existing implementations

Perfect for Diverse Applications

For comprehensive information about applications across our entire Biometric Calculator suite, see our main Biometric Calculator page.

🏥 Healthcare & Clinical Applications

Preventive Medicine: Early identification of accelerated aging
Clinical Trials: Biological age assessment in research studies
Patient Monitoring: Track biological age changes over time
Risk Assessment: Identify patients at higher mortality risk
Treatment Planning: Personalized interventions based on biological age

💪 Wellness & Fitness Platforms

Health Optimization: Personalized recommendations based on biological age
Progress Tracking: Monitor biological age improvements with lifestyle changes
Motivation Tools: Show users their biological vs. chronological age
Goal Setting: Age-specific health and fitness targets
Lifestyle Coaching: Evidence-based recommendations for aging well

🔬 Research & Academic Institutions

Aging Research: Large-scale studies of biological aging patterns
Intervention Studies: Evaluate the impact of treatments on biological age
Population Health: Assess aging patterns across different demographics
Epidemiological Studies: Investigate factors affecting biological aging
Longevity Research: Study factors that influence healthy aging

🏢 Enterprise Applications

Insurance Platforms: Risk assessment based on biological age
Corporate Wellness: Employee health monitoring and intervention
Health Technology: Integration with wearables and health apps
Pharmaceutical Research: Drug development and clinical trials
Government Health Programs: Population health monitoring

Technical Excellence

For comprehensive technical details about our entire Biometric Calculator suite, see our main Biometric Calculator page.

🚀 High-Performance Infrastructure

AWS-Powered: Enterprise-grade cloud infrastructure
99.9% Uptime: Reliable service with automatic failover
Millisecond Response: Calculations complete within milliseconds
Scalable: Handles high volumes for both small and large applications

🔒 Enterprise Security

Encrypted Transmission: All data transmitted securely via HTTPS
API Key Authentication: Secure access control with unique keys
Data Privacy: No personal data stored or logged
HIPAA Compliant: Suitable for healthcare applications

📊 Comprehensive Results

PhenoAge returns detailed biological age assessments:

{
  "biological": 42.92,
  "chronological": 49.17,
  "difference": -6.25,
  "PhenoAge1": 41.77,
  "adjustedPhenoAge1": 41.35,
  "PhenoAge2": 43.38,
  "adjustedPhenoAge2": 42.92
}

Getting Started with PhenoAge

1. Simple Integration

PhenoAge uses a straightforward REST API with comprehensive biomarker inputs:

curl -X POST "https://api.lincolncannon.co/biometric/calculate" \
  -H "Content-Type: application/json" \
  -H "x-api-key: YOUR_API_KEY" \
  -d '{
    "TestType": "PhenoAge",
    "BirthDate": "1974-12-01",
    "TestDate": "2024-01-31",
    "ALB": 4.5,
    "ALP": 85,
    "CR": 1.11,
    "CRP": 0.88,
    "GLU": 92,
    "LYMPH_PERCENT": 36,
    "MCV": 90,
    "RDW": 12.9,
    "WBC": 5.1
  }'

2. Comprehensive Documentation

API Reference: Complete endpoint documentation
Code Examples: JavaScript, Python, Java, and more
Integration Guides: Step-by-step implementation instructions
Best Practices: Optimization and error handling tips

3. Flexible Implementation

RESTful API: Standard HTTP requests
JSON Format: Easy-to-parse responses
Legacy Support: Backward compatibility with existing implementations
Error Handling: Comprehensive error codes and messages
Rate Limiting: Built-in protection against abuse

Learn more about our PhenoAge Calculator API.

Scientific Validation

📚 Peer-Reviewed Research

PhenoAge is based on research published in leading medical journals:

Levine, M. E. et al. (2018): “A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: A cohort study.” PLOS Medicine
Diverse Populations: Validated across different ethnicities and age groups
Clinical Outcomes: Predicts all-cause and cause-specific mortality

🎯 Clinical Applications

PhenoAge has been successfully used in:

Clinical Research: Large-scale studies of aging interventions
Preventive Medicine: Early identification of health risks
Population Health: Assessment of aging patterns across demographics
Drug Development: Evaluation of anti-aging interventions

Learn more about the PhenoAge scientific foundation.

Pricing & Support

For complete pricing information and support details across our entire Biometric Calculator suite, please visit our main Biometric Calculator page.

Our pricing includes flexible monthly and annual plans with multiple volume tiers designed to scale with your needs. All plans provide access to the complete Biometric Calculator suite with comprehensive support and documentation.

Ready to Add Biological Age Assessment?

Join leading healthcare providers, researchers, and wellness platforms using PhenoAge to deliver scientifically-validated biological age assessments in their applications. Contact Lincoln Cannon LLC to get started today!

Scientifically-validated biological age assessment. Built for accuracy. Trusted by researchers and healthcare providers worldwide.

Explore our complete Biometric Calculator suite:

Biometric Calculator Overview - Complete suite information
ChronoAge Calculator - Precise chronological age calculation
LinAge Calculator - Advanced biological age with 50+ biomarkers